ODCs

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2 OMIM references -
2 associated genes
10 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 4

1 OMIM reference -
1 associated gene
8 signs/symptoms

Epidermolytic ichthyosis

Ichthyosis hystrix of Curth-Macklin

KRT1	(UniProt - OMIM)		KRT1	(UniProt - OMIM)
KRT10	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	KRT10	(0.49)	KRT1

Citations in the biomedical literature:

Epidermolytic ichthyosis		Ichthyosis hystrix of Curth-Macklin
	Synonym(s): - BCIE - Bullous congenital ichthyosiform erythroderma - Bullous congenital ichthyosiform erythroderma of Brock - Bullous ichthyosis - EHK - EI - Epidermolytic hyperkeratosis		Synonym(s): - Ichthyosis hystrix, Curth-Macklin type

	Classification (Orphanet): - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C536088


COMMON SIGNS	- Autosomal dominant inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Ichthyosis / ichthyosiform dermatitis

Epidermolytic ichthyosis		Ichthyosis hystrix of Curth-Macklin
	Very frequent - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment - Weight loss / loss of appetite / break in weight curve / general health alteration Frequent - Pigmented naevi / naevus pigmentosus / lentigo Occasional - Follicular / conjunctival hamartomas - Palmoplantar hyperkeratosis / keratoderma		Very frequent - Follicular / erythematous / edematous papules / milium Frequent - Abnormal fingernails - Contractures / cramps / trismus / tetania / claudication / opisthotonos Occasional - Gangrena / necrosis